The SARS-CoV-2 infection may behave differently in pregnant and postpartum women in the short and long term. Several risk factors or medication use can interfere on disease' evolution and vertical transmission. Thus, due the current pandemic and the scarcity of scientific studies involving pregnant women with covid-19 or positive serology, combined with the need to elucidate the behavior of this viral infection in pregnant women in our population, this study aims to evaluate the clinical and laboratory evolution, transplacental passage, gestational and neonatal outcomes in pregnancies with positive SARS-CoV-2.
Study Type
OBSERVATIONAL
Enrollment
500
Serology test of SARS-CoV-2 for pregnant women
Rossana P Fracisco
São Paulo, Brazil
RECRUITINGDiagnostic test: SARS-CoV-2 serology
Number of pregnant women with COVID-19 infection assessed with a serology test
Time frame: 01/07/2021
Laboratorial analysis of maternal and umbilical cord blood
Number of participants with transplacental passage of SARS-CoV-2 assessed by laboratorial analysis of maternal and umbilical cord blood
Time frame: 01/07/2021
Laboratorial analysis of Amniotic Fluid
Number of participants with transplacental passage of SARS-CoV-2 assessed by amniotic fluid analysis
Time frame: 01/07/2021
Placenta biopsy
Number of participants with transplacental passage of SARS-CoV-2 assessed by placenta biopsy
Time frame: 01/07/2021
Laboratorial analysis of colostrum
Number of participants with transplacental passage of SARS-CoV-2 assessed by colostrum
Time frame: 01/07/2021
Ovarian remains biopsy
Number of participants with transplacental passage of SARS-CoV-2 assessed by ovarian remains biopsy in cases of abortion and fetal death.
Time frame: 01/07/2021
Blood count analysis
Number of participants with adverse events assessed by the blood count analysis after SARS-CoV-2 infection.
Time frame: 01/07/2021
Laboratorial analysis of thyroid hormones
Number of participants with adverse events assessed by the thyroid hormones analysis after SARS-CoV-2 infection.
Time frame: 01/07/2021
PCR analysis
Number of participants with adverse events assessed by the PCR analysis after SARS-CoV-2 infection.
Time frame: 01/07/2021
Laboratorial analysis of Interleukins
Number of participants with adverse events assessed by the interleukins analysis after SARS-CoV-2 infection.
Time frame: 01/07/2021
Fetal morphology ultrasound
Number of babies with developmental changes and fetal morphology alterations assessed by ultrasound after the maternal diagnosis of Covid-19.
Time frame: 01/07/2021
Placental insufficiency ultrasound
Number of participants with placental insufficiency and altered fetal well-being assessed by ultrasound after a positive maternal diagnosis of SARS-CoV-2.
Time frame: 01/07/2021
Type of delivery
Number of patients that performed natural delivery or caesarean, assessed by a structured questionnaire.
Time frame: 01/07/2021
Gestational age at delivery
Gestational age at delivery and premature cases, assessed by a structured questionnaire.
Time frame: 01/07/2021
Apgar score
Newborn's apgar score at first, second and third minutes after birth, assessed by a Apgar Score Scale (0 = minimum value and 10 = maximum value)
Time frame: 01/07/2021
Newborn weight
Newborn's weight immediately after birth, assessed by a pediatric weight balance
Time frame: 01/07/2021
Fatigue Scale
Number of patients with persistent symptoms of fatigue, assessed by a Fatigue Structured Scale
Time frame: 01/07/2021
Prone Position
Number of patients who needed intervention with a prone position during hospitalization, accessed by the medical record data.
Time frame: 01/07/2021
Use of mechanical ventilation
Number of patients who needed intervention with a mechanical ventilation and oxygen during hospitalization, accessed by the medical record data.
Time frame: 01/07/2021
Pulmonary Ultrasound
Number of patients with alterations in pulmonary ultrasound and chest tomography resulting from SARS-Cov2 infection.
Time frame: 01/07/2021
Chest Tomography
Number of patients with alterations in pulmonary ultrasound and chest tomography resulting from SARS-Cov2 infection.
Time frame: 01/07/2021
Anxious and depressive symptoms - HAD questionnaire
Number of patients with anxious and depressive symptoms in prenatal and postpartum, assessed by Hospital Anxiety and Depression Scale.
Time frame: 01/07/2021
Heart rate variability electrocardiogram
Number of patients with cardiac autonomic modulation, assessed by a heart rate variability electrocardiogram.
Time frame: 01/07/2021
Laboratorial analysis of glycated hemoglobin
Number of patients with endocrine system alterations after the Covid-19 infection, assessed by laboratorial analysis of glycated hemoglobin
Time frame: 01/07/2021
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