Epigenetics in Lupus Nephritis

University of Göttingen60 enrolled

Overview

This is a translational study for the identification of epigenetic changes detectable in sera of patients suffering from Systemic Lupus erythematosus. The aim of the study is to analyze whether circulating DNA fragments are 1) different in patients with or without Lupus nephritis and 2) present and detectable in the circulation before the development of Lupus nephritis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Systemic Lupus Erythematosus Lupus Nephritis

Interventions

Blood samplingDIAGNOSTIC_TEST

Blood sampling will be performed to allow analyses of epigenetic markers

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of systemic lupus erythematosus according to the current classification criteria * a subgroup requires the presence of Lupus nephritis (no restriction to specific LN histologic subtypes) Exclusion Criteria: * patients not able or unwilling to provide written informed consent

Locations (1)

University Medical Center Göttingen

Göttingen, Lower Saxony, Germany

RECRUITING

Outcomes

Primary Outcomes

Methylated CpG-rich DNA fragments

it will be analyzed whether circulating CpG-rich DNA fragments are present in patients' blood

Time frame: 12 months

Central Contacts

PETER KORSTEN, MD

CONTACT

055139 peter.korsten@med.uni-goettingen.de

Data from ClinicalTrials.gov

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