Fomepizole Dosing During Continuous Renal Replacement Therapy (CRRT)

Oslo University Hospital11 enrolled

Overview

The project is a prospective observation study of patients with suspected or confirmed toxic alcohol poisoning treated with fomepizole and continuous renal replacement therapy (CRRT)

Study Type

OBSERVATIONAL

Enrollment

Conditions

Toxic Alcohol Poisoning

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients (over 18 year) with suspected or confirmed toxic alcohol poisoning treated with fomepizole and CRRT. Exclusion Criteria: * Patients who wish to withdraw from the study

Locations (1)

Oslo University Hospital

Oslo, Norway

Outcomes

Primary Outcomes

Measure minimum plasma concentration of fomepizole

Plasma samples will be obtained up to every hour and before fomepizole is given

Time frame: through study completion, up to 72 hours

Secondary Outcomes

Continuous renal replacement therapy (CRRT) clearance of fomepizole

Plasma and dialysat samples will be obtained up to every hour

Time frame: through study completion, up to 72 hours

Determine saturation/sieving coefficient of fomepizole

Plasma and dialysat samples will be obtained up to every hour

Time frame: through study completion, up to 72 hours

Data from ClinicalTrials.gov

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