Bone Healing in Immediate Dental Implants

CMH Lahore Medical College and Institute of Dentistry12 enrolled

Overview

To study the effect of platelet-rich plasma concentrate on marginal bone loss and bone mineral density in immediate implant placement through CBCT.

12 subjects were equally categorized into two groups. Group, I was the control group; whereas, the subjects in Group II received Platelet Rich Plasma (PRP) therapy. All subjects were given a standard treatment with single implant system. Inserted implants were analyzed through Cone Beam Computerized Tomography (CBCT). Records were registered at the baseline, at 12th week before functional loading and 26th week after functional loading.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Alveolar Bone Loss Platelet Rich Plasma

Interventions

PRP injectionBIOLOGICAL

PRP was prepared using patient's blood and mixed with saline or mixture of calcium chloride and thrombin to form a liquid solution; in order to inject at the surgical site after placement of implant.

Automated blood cell separator to extract PRPDEVICE

Blood was withdrawn from antecubital vein and mixed with anticoagulant. Blood sample was then centrifuged to obtain platelet rich plasma which was injected at surgical site after implant placement.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients maintaining good oral hygiene, having adequate bone quantity at the implant site, uneventful extraction Exclusion Criteria: * Active infection around implant site, immunocompromised state, with current major systemic disease (uncontrolled diabetes, rheumatoid arthritis, etc.) or oral pathologies, history of bleeding disorders or on anticoagulant therapy, or patients on bisphosphonates were excluded from the study

Locations (1)

Institute of Dentistry; CMH Lahore Medical College

Lahore, Punjab Province, Pakistan

Outcomes

Primary Outcomes

Measurement of bone loss at baseline (12 weeks) and later at 26weeks

Measurement at mesial in mm

Time frame: Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT

Secondary Outcomes

Measurement of bone loss at baseline (12 weeks) and later at 26weeks

Measurement at distal in mm

Time frame: Baseline -before functional loading at 12 weeks & at 26 weeks- after functional loading to assess changes in marginal bone loss in sagittal view using CBCT

Data from ClinicalTrials.gov

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