Research on the Effect and Mechanism of Aerobic Exercise on PD

The First Hospital of Jilin University30 enrolled

Overview

This trial is expected to recruit patients with primary Parkinson's disease and give them four consecutive weeks of aerobic exercise to observe its effect on Parkinson's disease and explore its mechanism

This trial is expected to recruit patients with primary Parkinson's disease who are distributed into tremor group and stiff group and give them the same kind of four consecutive weeks of aerobic exercise to observe its effect on Parkinson's disease and explore its mechanism

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Parkinson's Disease Physical Exercise

Interventions

aerobic exerciseBEHAVIORAL

Participants ride an Acon-8650 model exercise bicycle 3 times a week for 1 hour each time for four consecutive weeks

Eligibility

Sex: ALLMin age: 55 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Participants were diagnosed primary PD according to the 2015 MDS diagnostic criteria * Participants are between 55 and 65 years old Exclusion Criteria: * Severe heart * liver dysfunction * kidney dysfunction * severe cognitive dysfunction * severe anxiety and depression * history of mental illness * history of cerebral infarction or ischemic attack in the past three months * acute myocardial infarction or acute coronary in the past three months * Parkinson's Pulse syndrome * medication history (drugs that improve blood circulation in the brain and increase the excitability of the nervous system)

Locations (1)

FirstJilinU

Changchun, China

Outcomes

Primary Outcomes

Movement Disorder Society-United Parkinson's Disease Rating Scale (MDS-UPDRS)

to assess the motor and nonmotor function of PD,0-200 scores,the higher scores mean lower function

Time frame: changes of MDS-UPDRS score from baseline at four weeks

Montreal Cognitive Assessing(MoCA) score

to assess the cognitive function of PD,0-30 scores,the higher scores mean better function

Time frame: changes of MoCA score from baseline at four weeks

The Epworth Sleeping Scale(ESS)

to assess the degree of drowsiness, 0-24 scores, the higher scores mean severe drowsiness

Time frame: changes of ESS score from baseline at four weeks

Non-Motor Symptom Scale (NMSS)

to assess the non-motor of PD , 0-120 scores, the higher scores mean severe non-motor damage

Time frame: changes of NMSS score from baseline at four weeks

Secondary Outcomes

cerebral blood variation by Head MRI

to assess the cerebral blood variation by head MRI

Time frame: changes of the cerebral blood from baseline at four weeks

cerebral blood flow velocity

cerebral blood flow velocity is recorded using transcranial Doppler and a servo-controlled plethysmograph respectively.

Time frame: changes of the cerebral blood flow velocity from baseline at four weeks

the level of arterial blood pressure

arterial blood pressure is recorded using transcranial Doppler and a servo-controlled plethysmograph respectively. Both systolic and diastolic pressures will be assessed during the study period.

Data from ClinicalTrials.gov

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