It is an observational trial on 500 subjects. The purpose of this trial is to assess the prevalence of non-alcoholic steatohepatitis (NASH) in subjects with different classes of obesity.
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of chronic liver disease due to an increase in the prevalence of obesity. The development of NASH leads to an increase in morbidity and mortality. Since patients with obesity are at an increased risk of NASH, the aim of this trial is to assess the prevalence of NASH in this class of patients.
Study Type
OBSERVATIONAL
Enrollment
500
Biopsy of the liver to assess for Non-alcoholic steatohepatitis
University of Rome Sapienza
Roma, Italy
Catholic University School of Medicine
Rome, Italy
Prevalence of NASH
Prevalence of NASH in a cohort of patients with different classes of obesity
Time frame: 6 months
Assessment of lipid profile
Assessment of triglycerides, total cholesterol, LDL and HDL cholesterol
Time frame: 6 months
Assessment of glycemic profile
Assessment of fasting glucose
Time frame: 6 months
Assessment of glycated hemoglobin
Assessment of glycated hemoglobin
Time frame: 6 months
Assessment of liver enzymes
Assessment of AST, ALT, GGT
Time frame: 6 months
Assessment of insulin
Assessment of fasting insulin
Time frame: 6 months
Assessment of metabolic profile
Assessment of HOMA-IR index
Time frame: 6 months
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