Background: Patients with type 2 diabetes mellitus (T2DM) are at 2- to 4-fold higher risk of cardiovascular mortality compared with non-diabetic subjects. Cardiovascular disease (CVD) is the main cause of death in almost half of diabetic population in Spain. Female patients with T2DM have up to 40% excess risk of CVD compared with men and the causes are still unknown. It is argued that a tight control of cardiovascular risk factors could improve the situation. Hypothesis: The cardiovascular risk factors management in women with T2DM is different than in men with T2DM. Aims: To assess the therapeutic approach of cardiovascular risk factors and the occurrence of cardiovascular events among women in comparison to men with T2DM. Methodology: Observational study based on clinical records of primary health care from T2DM patients in Catalonia (2007-2013). Source: SIDIAP database. Analysis: The two study groups (women and men) will be matched to ensure balance in terms of basal comorbidities and previous cardiovascular disease in order to describe the study group characteristics and to perform a multivariate modeling approach. Applicability and Relevance: This study is intended to serve to identify the points of improvement of the cardiovascular risk factors therapeutic approach in women.
Study Type
OBSERVATIONAL
Enrollment
300,000
IDIAP Jordi Gol
Barcelona, Spain
Age
Age registered on the date of data extraction (DTALL-30Jun)
Time frame: 2007-2013
Gender
Gender registered on the date of data extraction (DTALL-30Jun)
Time frame: 2007-2013
Date of DM diagnosis
DM onset date registered on the date of data extraction (DTALL-30Jun)
Time frame: 2007-2013
Diagnosis of the most common cardiovascular risk factors
High Blood Pressure (\>140/90mm Hg), Dyslipidaemia, Smoking and Obesity
Time frame: 2007-2013
Level of of glycated haemoglobin (HbA1c)
The value closer and prior to data extraction (DTALL-30Jun) will be considered and a window of up to a year before the DTALL accepted
Time frame: 2007-2013
Average of the three last measurements of systolic and diastolic blood pressure
A window of up to a year before the DTALL date will be accepted. If there are no 3BP measurements, the ones available closer to DTALL will be accepted.
Time frame: 2007-2013
Levels of Total Cholesterol (TC), LDL Cholesterol (LDL-C), HDL Cholesterol (HDL-C) and triglycerides (TGC)
A window of up to a year before the DTALL date will be accepted
Time frame: 2007-2013
Body Mass Index (BMI)
A window of up to a year before the DTALL-30Jun will be accepted. Height will be measured in m and weight in kg
Time frame: 2007-2013
Kidney function: glomerular filtration estimated by MDRD
The value closer and prior to data extraction (DTALL-30Jun) will be considered and a window of up to a year before the DTALL accepted
Time frame: 2007-2013
Kidney function: urinary albumin excretion (albumin/creatinine ratio)
The value closer and prior to data extraction (DTALL-30Jun) will be considered and a window of up to a year before the DTALL accepted
Time frame: 2007-2013
Use of hypoglycaemic agents and insulin on the DTALL-30Jun
Data of use will be obtained from the pharmacy billing of the Catalan Health Service (CatSalut).
Time frame: 2007-2013
Use of antihypertensive, hypolipidemic, antiplatelet and anticoagulant agents on the DTALL-30Jun
Data of use will be obtained from the pharmacy billing of the Catalan Health Service (CatSalut)
Time frame: 2007-2013
Cardiovascular disease registered on the DTALL-30Jun
Coronary artery disease, cerebrovascular disease and peripheral artery disease with codes
Time frame: 2007-2013
Causes of mortality in the population with type 2 diabetes during the study period
Causes of mortality in the population with type 2 diabetes during the study period
Time frame: 2007-2013
Diagnosis of Diabetic retinopathy
Diagnosis of Diabetic retinopathy
Time frame: 2007-2013
Number of visits with the primary care team in the previous 12 months
A window of up to a year before the DTALL-30Jun will be considered
Time frame: 2007-2013
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