Prevalence of SARS-CoV-2 Genome in Tears of Asymptomatic and Moderately Symptomatic COVID-19 Patients

Assistance Publique - Hôpitaux de Paris534 enrolled

Overview

To evaluate the prevalence of SARS-CoV-2 genome in patients with asymptomatic and moderately symptomatic COVID19.

Patients attending to the COVID19 screening facility of Paris South University hospital and willing to participate to the study will have both nasopharyngeal and conjunctival swab for SARS-CV-2 genome detection using PCR. The project will evaluate the prevalence of positive conjunctival swabs in patients with positive nasopharyngeal swab. These results will be corelated to symptoms of disease assessed with a standardized questionnaire.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

534

Conditions

SARS-CoV-2

Interventions

conjunctival swabDIAGNOSTIC_TEST

Patients will have conjunctival swab for SARS-CV-2 genome detection

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients receiving diagnostic nasopharyngeal PCR for COVID-19 as part of the usual care * Age ≥ 18. * Information and signature of consent * Affiliated with a social security scheme or entitled Exclusion Criteria: * Refusal to participate in the study * Eye surgery less than 3 months old * Unable to give informed consent * No coverage through the health insurance system * Patient under judicial protection * Patient on AME

Locations (1)

Hôpital Bicêtre

Le Kremlin-Bicêtre, France

Outcomes

Primary Outcomes

presence of SARS-CoV-2 genome in tears

Prevalence of SARS-CoV-2 genome in tears

Time frame: at the end of the study, an average of 1 year

Secondary Outcomes

presence of systemic symptoms evaluated at the time of making an appointment by a systematic standardized interrogation

correlation between systemic symptoms (fever, chills, sweating, muscle aches, headache, runny or stuffy nose, cough, sore throat, asthenia, anosmia, agueusia, unusual shortness of breath, skin rash diarrhea, nausea vomiting) and positive conjunctival swab

Time frame: at the end of the study, an average of 1 year

assessement of viral load levels

correlation between nasopharyngeal viral load and conjunctival load (indirectly assessed with cycle thresholds quantification method)

Time frame: at the end of the study, an average of 1 year

Data from ClinicalTrials.gov

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