To evaluate host-immune biomarkers including TRAIL, IP-10, CRP and their computational integration for predicting COVID-19 and disease severity in patients with PCR-confirmed COVID-19.
Study Type
OBSERVATIONAL
Enrollment
173
Saarland University
Homburg, Germany
Differential expression of biomarkers between COVID-19 and controls
Differential expression of TRAIL, IP-10, CRP, and their computational integration in subjects with COVID-19, as compared to control subjects.
Time frame: up to 90 days
Differential expression of biomarkers between severe and non-severe COVID-19
Differential expression of TRAIL, IP-10, CRP, and their computational integration in subjects with COVID-19, who require more extensive medical intervention (i.e., exhibit severe symptoms), i.e. severe infection vs. non-severe infection
Time frame: up to 90 days
Correlation of biomarkers with disease severity
Correlation between host-immune biomarkers including TRAIL, IP-10, CRP, and their computational integration for predicting disease severity in patients with COVID-19, where measures of severity include ICU admission, respiratory failure, mechanical ventilation, septic shock, non-respiratory organ failure, and mortality.
Time frame: up to 90 days
Biomarkers depending on therapy
Differential expression of TRAIL, IP-10, CRP, and their computational integration in subjects with COVID-19 with or without specific therapy.
Time frame: up to 90 days
Biomarkers depending on bacterial co-infection
Differential expression of TRAIL, IP-10, CRP, and their computational integration in subjects with COVID-19 with or without bacterial co-infection.
Time frame: up to 90 days
Correlation of biomarkers with viral load
Correlation between host-immune biomarkers including TRAIL, IP-10, CRP, and their computational integration with infectiousness, i.e. e.g. viral load.
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Time frame: up to 90 days