This study is being conducted in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) to determine if intravitreal (IVT) injections of ANX007 reduce GA lesion growth rate. The results will be used to guide further development of ANX007 in participants with geographic atrophy. The total duration of participation is expected to be approximately 19 months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
270
Form: solution for injection; Route of Administration: IVT
Form and Route of Administration: pressure to mimic IVT injection
GA lesion growth rate
Change in GA lesion area as assessed by fundus autofluorescence (FAF)
Time frame: Baseline to Month 12
Safety: Participants with treatment-emergent adverse events (TEAEs)
Number of participants with TEAEs
Time frame: Baseline to Month 18
Best corrected visual acuity (BCVA)
Change from baseline in BCVA as assessed by the Early Treatment Diabetic Retinopathy Study (ETDRS) test chart
Time frame: Baseline to Month 18
Low-luminance BCVA (LL-BCVA)
Change from baseline in LL-BCVA
Time frame: Baseline to Month 18
Low-luminance visual acuity deficit (LL-VD)
Change from baseline in LL-VD
Time frame: Baseline to Month 18
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