The aim of this research is to study and compare the efficacy and safety of single injection erector spinae plane block and thoracic paravertebral block in prevention of post herpetic neuralgia in patients with acute thoracic herpes zoster.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
90
Patients of this group will receive standard treatment for herpes zoster which include acyclovir 800 mg, 5 times daily administered orally within the first 72 hours and analgesics as needed
Patients of this group will receive 25 mg bupivacaine 0.5%, plus 8 mg dexamethasone in a total volume of 10 ml (The final concentration of bupivacaine will be 0.25%) to be injected beneath the erector spinae muscle sheath) at the desired level under ultrasonography.
Patients of this group will receive 25 mg bupivacaine 0.5% , plus 8mg dexamethasone in a total volume of 10 ml(The final concentration of bupivacaine will be 0.25%) to be injected in the Paravertebral space at desired level under ultrasonography
Tanta University Hospitals
Tanta, Egypt
RECRUITINGThe incidence of post herpetic neuralgia (PHN)
Persistent herpetic pain after 3 months will reported as post herpetic neuralgia (PHN)
Time frame: 3 months
Visual Analog Scale
Visual Analog Scale (VAS) at baseline, 3, 4, 12, 24 weeks
Time frame: 6 months
Total consumption of rescue analgesia
Rescue analgesia in the form of Acetaminophen in a dose of 1,000 mg will be given if Visual Analog Scale (VAS) ≥4
Time frame: 6 months
The times of complete resolution of pain
The times of complete resolution of pain (from the date of block until complete disappearance of herpetic pain)
Time frame: 3 months
Adverse effects and complications
* Hypotension * Pneumothorax * Local anesthetic toxicity * Respiratory depression
Time frame: 1 day
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