This is a prospective cohort study of pregnant patients at an urban academic center diagnosed with perinatal COVID-19 infection, followed up to 6 weeks postpartum.
This proposal aims to provide a multi-faceted approach to addressing perinatal COVID-19 infection by (1) improving our understanding of SARS-CoV-2 antibody specificity and durability over the course of pregnancy/postpartum in mother/baby dyad (2) understanding the downstream implications of maternal systemic inflammatory response with COVID-19 infection through study of fetal inflammatory response, placental pathology, and perinatal outcomes, and (3) to evaluate the interplay between socioeconomic characteristics, COVID-19, and early neonatal outcomes. (4) Evaluate antibody generation and durability in pregnant/breastfeeding women who receive any form of the COVID-19 vaccine
Study Type
OBSERVATIONAL
Enrollment
105
COVID-19 exposure during pregnancy
Receipt of any COVID-19 vaccine
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States
Maternal COVID-19 serology (IgG and IgM)
IgG/IgM time profile through pregnancy up to 6 weeks post partum for those exposed to COVID-19
Time frame: 6 weeks post partum
Maternal/neonatal IgG and IgM concordance
IgG/IgM at delivery in mother/neonate through maternal and cord blood sampling
Time frame: Delivery
Maternal COVID serology time/profile following vaccination
Baseline, 1m, 3m, 6m post second vaccine dose
Time frame: 6 months
Breastmilk Serology
Breastmilk IgG and IgA time profile following COVID vaccine in breastfeeding women
Time frame: 6months
Breastmilk Serology
COVID-19 IgG and IgA in breast milk
Time frame: Delivery
Breastmilk Serology
COVID-19 IgG and IgA in breastmilk
Time frame: 6 weeks post partum
Cytokine
Compare maternal COVID (+) and COVID (-) cytokine panel
Time frame: Delivery
Neonatal cytokine
Compare cordblood cytokine panel between COVID(+) and COVID (-) at delivery
Time frame: Delivery
COVID disease vs vaccination immune response
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Compare maternal IgG concentration time/profile in those with COVID disease vs COVID vaccine
Time frame: 6 months
COVID vaccine in pregnant vs nonpregnant
Compare maternal IgG concentration/time profile in pregnant vs non-pregnant women with vaccine
Time frame: 6 months