The investigators plan to perform multi-omics technologies, including genomic, transcriptomic, epigenomic and proteomic methods, in patients with metastatic prostate cancer, aiming at uncovering the mechanism of the tumor progression, identifying distinct tumor subtypes and finding new treatment targets.
Prostate cancer is the commonest malignancy and the second leading cause of tumor-related death among males worldwide. Though patients with early stage prostate cancer can obtain satisfactory therapeutic efficacy from radical prostatectomy or radiotherapy, the prognosis of men with metastatic prostate cancer (mPCa), especially metastatic castration-resistant prostate cancer (mCRPC), is still poor. Recent years have witnessed the rapid development of the high-throughput technologies, including genomic, transcriptomic, epigenomic and proteomic methods. These techniques are promising in uncovering the mechanism of the tumor progression, identifying distinct tumor subtypes and finding new treatment targets. In the current prospective study, the investigators plan to perform multi-omics technologies in patients with mPCa, aiming at uncovering the mechanism of the tumor progression, identifying distinct tumor subtypes and finding new treatment targets.
Study Type
OBSERVATIONAL
Enrollment
100
Genetic profiling results
Mutation identified via whole-genome sequencing will be recored.
Time frame: From baseline (initial diagnosis of PCa), until study completion (48 months)
Transcriptional profiling results
Determining the transcriptomic information of metastatic prostate cancer by performing whole transcriptome sequencing
Time frame: From baseline (initial diagnosis of PCa), until study completion (48 months)
Epigenomic profiling results
Determining the epigenomic status of specific genes by performing DNA-methylation sequencing
Time frame: From baseline (initial diagnosis of PCa), until study completion (48 months)
Protein expression results
Determing the expression status of centain proteins by performing immunohistochemistry in prostate biopsy specimen
Time frame: From baseline (initial diagnosis of PCa), until study completion (48 months)
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