PHOTOTHERAPY VERSUS PREGABALIN IN TREATMENT OF REFRACTORY UREAMIC PRURITIS

Alexandria University40 enrolled

Overview

Patients will be randomly assigned into 2 groups: 1. Group A: (20 patients) will receive NB UVB phototherapy 3 sessions per week for 2 months. 2. Group B: (20 patients) will receive pregabalin oral therapy (50mg after each dialysis session) for 2 months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Refractory Uremic Pruritis

Interventions

NB UVB phototherapyDEVICE

ultraviolet phototherapy sessions

PregabalinDRUG

oral medication

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age: 20-60 years. 2. End stage renal disease (the last stage(stage 5) of chronic disease which means kidneys are only functioning at 10 to 15 percent of their normal capacity and dialysis or kidney transplant is necessary to stay alive). 3. Refractory uremic pruritis. Exclusion Criteria: 1. Other causes of pruritis (Dermatological or systemic) e.g. atopic, cholestatic liver disease. 2. Photosensitivity. 3. Contraindication or allergy to pregabalin. 4. Patients on antipruritic drugs e.g. antihistamines, steroids, emollients, opioid agonists.

Locations (1)

Faculty of Medicine

Alexandria, Egypt

RECRUITING

Outcomes

Primary Outcomes

5 D-itching scale

assessment of degree, duration, direction, disability and distribution of itching

Time frame: two month

Central Contacts

marwa eldeeb

CONTACT

01200029774 marwa.eldeeb16@alexmed.edu.eg

Data from ClinicalTrials.gov

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