A study of the relation between genetic biomarkers and child development in Taiwan.
The interaction between gene and environment (G×E) can be a very complicated process that influences child development. As a pilot study of child development biomarkers, this study investigates genes related to child development.
Study Type
OBSERVATIONAL
Enrollment
446
Chang Gung Memorial Hospital
Taoyuan District, Taiwan
RECRUITINGScores of cognitive function 1
Bayley Scales of Infant and Toddler Development (Scores from 0 to 140, higher scores mean a better outcome.)
Time frame: baseline
Scores of cognitive function (2 y/o to 6 y/o)
Wechsler Preschool and Primary Scale of Intelligence (Scores from 0 to 200, higher scores mean a better outcome.)
Time frame: baseline
Scores of cognitive function (6 y/o to 16 y/o)
Wechsler Intelligence Scale for Children (Scores from 0 to 200, higher scores mean a better outcome.)
Time frame: baseline
Scores of cognitive function 3
Test of Nonverbal Intelligence-Fourth Edition (Scores from 0 to 60, higher scores mean a better outcome.)
Time frame: baseline
Scores of cognitive psychological function
Cantab MOT, PAL, SWM, SOC tests
Time frame: baseline
Scores of language function
Peabody Picture Vocabulary Test-Revised (Scores from 0 to 124, higher scores mean a better outcome.)
Time frame: baseline
Scores of language function 2
Preschool Language Impaired Scale(PLS)/Language Impaired Scale(LS) (PLS: Scores from 0 to 65, higher scores mean a better outcome. LS: Scores from 0 to 73, higher scores mean a better outcome.)
Time frame: baseline
Scores of general development
Comprehensive Developmental Inventory for Infants and Toddlers (Higher scores mean a better outcome.)
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Time frame: baseline
Scores of social behavior 1
Clancy Behavior Scale (Scores from 0 to 42, lower scores mean a better outcome.)
Time frame: baseline
Scores of social behavior 2
Swanson, Nolan, and Pelham, Version IV (Lower scores mean a better outcome.)
Time frame: baseline
Scores of motor ability 1
The Berry-Buktenica Developmental Test of Visual-Motor Integration (Scores from 0 to 81, Higher scores mean a better outcome.)
Time frame: baseline
Scores of motor ability 2
Measure of Grip and Grasp (Higher scores mean a better outcome.)
Time frame: baseline
Gene test (Mircoarray)
Microarray (Use Axiom Genome-Wide TWB 2.0 Array Plate (TWB 2.0) to analyze SNPs of disease-related biomarkers.)
Time frame: baseline
Gene test (WES1)
Whole-Exome Sequencing (Use Burrows-Wheeler Aligner (BWA) 85 to screen out the variant discovery and genotyping.)
Time frame: baseline
Gene test (WES2)
Whole-Exome Sequencing (Use Samtools86 to screen out the variant discovery and genotyping.)
Time frame: baseline
Gene test (WES3)
Whole-Exome Sequencing (Use Picard to screen out the variant discovery and genotyping.)
Time frame: baseline
Gene test (WES4)
Whole-Exome Sequencing (Use Genome Analysis Toolkit (GATK) to screen out the variant discovery and genotyping.)
Time frame: baseline
Scores of participation(2-5 y/o)
Assessment of Preschool Children's Participation (Scores from 0 to 45, higher scores mean a better outcome.)
Time frame: baseline
Scores of participation(>6 y/o)
Children Assessment of Participation and Enjoyment and Preferences for Activity of Children (Higher scores mean a better outcome.)
Time frame: baseline
Scores of activities
Functional Independence Measure for Children (Scores from 18 to 126, higher scores mean a better outcome.)
Time frame: baseline
Scores of quality of life
Pediatric Quality of Life Inventory TM (Scores from 0 to 102, higher scores mean a better outcome.)
Time frame: baseline