Sarilumab Treatment In cytoKinE Storm Caused by Infection With COVID-19

Inclusion Criteria: 1. Written informed consent prior to performing study procedures. Oral consent will be accepted in order to avoid paper handling. Written consent by patient or representatives will be obtained as soon as possible. In the case of a vital emergency without the possibility of prior consent, a patient may be included in the study if the recommendations of the legislation are followed (RD 1090/2015, article 7), as stated in section 10.3 of the protocol. 2. Patient must be, in the investigator opinion, able to comply with all the protocol procedures. 3. Negative pregnancy test in case of fertile women\* 4. Age \>= 18 5. Infection by COVID-19 confirmed by rtPCR or other validated tests 6. Hospitalized (or documentation of a plan to admit to the hospital if the patient is in the emergency department) with illness of any duration, with evidence of pneumonia, and severe disease as defined by at least one of the following: 1. High oxygen requirements (face mask with reservoir, non-invasive mechanical ventilation or high flow nasal cannula) 2. Lymphocytes \< 0.8 x 109/L 3. Serum ferritin \> 300ng/mL 4. Increased levels of D-dimer (\> 1500 ng/mL) or D-dimer progressively increasing (over 3 consecutive measurements) and reaching ≥ 1000 ng/mL. 5. CPR \> 10 mg/dL, or increasing over 24 hours Exclusion Criteria: Patients with any of the following exclusion criteria could not be included in the trial: 1. Hypersensitivity to the active substance or any of the excipients listed in section 6 2. Treatment with anti-IL 6, anti-IL-6R antagonists, or with Janus kinase inhibitors (JAKi) in the past 30 days 3. Alkylating agents including cyclophosphamide (CYC) within 6 months of baseline 4. Cyclosporine (CsA), azathioprine (AZA) or mycophenolate mofetil (MMF) or leflunomide within 4 weeks of baseline. 5. Alkylating agents including cyclophosphamide (CYC) within 6 months of baseline 6. Tumor necrosis factor (TNF) inhibitors within 2-8 weeks (etanercept within 2 weeks, infliximab, certolizumab, golimumab, or adalimumab within 8 weeks), or after at least 5 half-lives have elapsed, whichever is longer. 7. Intravenous immunoglobulin (IVIG) within the past 5 months or plans to receive during the study period 8. Current use of chronic oral corticosteroids for a non-COVID-19-related condition in a dose higher than prednisone 10 mg or equivalent per day 9. Current treatment with conventional synthetic disease-modifying antirheumatic drugs (DMARDs)/immunosuppressive agents 10. Patients who have received immunosuppressive antibody therapy within the past 5 months, including intravenous immunoglobulin 11. AST/ALT values \> 5 x normal. 12. Neutropenia (\< 0.5 x 109/L). 13. Sever thrombocytopenia (\< 50 x 109/L). 14. Sepsis caused by an alternative pathogen. 15. Diverticulitis with risk of perforation. 16. Ongoing infectious dermatitis. 17. Patients with another active infection, including localized infections. 18. Pregnant or breast-feeding females will be excluded 19. Positive serology for following infection: HIV, Hepatitis B, or C.