Acute gastrointestinal bleeding is potentially lethal in liver cirrhosis. Accurate assessment of prognosis is critical in a timely fashion. A novel model, CAGIB score, has been developed based on our Chinese multicenter retrospective study. Now, a prospective, international multicenter, observational study will be performed to further compare the performance of CAGIB versus Child-Pugh and MELD scores for evaluating the in-hospital mortality of patients with liver cirrhosis and acute gastrointestinal bleeding.
Study Type
OBSERVATIONAL
Enrollment
3,000
The Wright Center for Graduate Medical Education, 501 S. Washington Avenue
Scranton, Pennsylvania, United States
NOT_YET_RECRUITINGSão Paulo State University (UNESP), Botucatu Medical School
São Paulo, São Paulo, Brazil
RECRUITINGBeijing Youan Hospital, Capital Medical University
Beijing, Beijing Municipality, China
RECRUITINGThe Seventh Medical Center of Chinese PLA General Hospital
Beijing, Beijing Municipality, China
NOT_YET_RECRUITINGFirst Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China
RECRUITINGUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
RECRUITINGFirst Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
RECRUITINGThe Six People's Hospital of Dalian
Dalian, Liaoning, China
RECRUITINGAir Force Hospital of Northern Theater Command
Shenyang, Liaoning, China
RECRUITINGGeneral Hospital of Northern Theater Command
Shenyang, Liaoning, China
RECRUITING...and 13 more locations
Mortality
Death caused by any events during hospitalizations.
Time frame: An average of 1-6 weeks, from admission to discharge
Failure to control bleeding within 5 days
Failure is defined as death or need to change therapy defined by one of the following criteria within 5 days: 1) Fresh hematemesis or nasogastric aspiration of ≥100 ml of fresh blood ≥2 h after the start of a specific drug treatment or therapeutic endoscopy; 2) Development of hypovolaemic shock; 3) 3g drop in hemoglobin (9% drop of hematocrit) within any 24 hours period if no transfusion is administered.
Time frame: 5 days
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