An Indian Multi-centric Phase IV Study to Assess the Safety of Crizanlizumab in Sickle Cell Disease Patients

Inclusion Criteria: * Signed informed consent * Male or female participant aged 16 years and older * Confirmed diagnosis of SCD by hemoglobin electrophoresis or high performance liquid chromatography (HPLC). All SCD genotypes are eligible. * History of VOC leading to healthcare visit prior to screening visit * Participants must meet the following central laboratory values at the screening visit: Absolute Neutrophil Count ≥1.0 x 109/L Platelet count ≥75 x 109/L Hemoglobin: for adults (Hb) ≥4.0 g/dL and for adolescents (Hb) ≥5.5 g/dL Glomerular filtration rate ≥ 45 mL/min/1.73 m2 using CKD-EPI formula Direct (conjugated) bilirubin \< 2.0 x ULN Alanine Aminotransferase (ALT) \< 3.0 x ULN * ECOG performance status ≤2 for adults and Karnofsky Performance Scale ≥ 50% for adolescents. Exclusion Criteria: * Contraindication or hypersensitivity to any drug or metabolites from similar class as study drug. History of severe hypersensitivity reaction to other monoclonal antibodies which in the opinion of the investigator may pose an increased risk of serious infusion reaction. * Participant has received crizanlizumab and/or other P-selectin inhibitor prior to the study or plans to receive it during the duration of the study. * Concurrent severe and/or uncontrolled medical conditions which, in the opinion of the Investigator, could cause unacceptable safety risks or compromise participation in the study. * Any condition which, in the opinion of the investigator, is likely to interfere with the successful collection of the measurements required for the study. * Participant has documented immunogenicity to a prior biological drug. * Participants who are on active treatment with Voxelotor, other investigational drug or other monoclonal antibody, or intend to initiate the same during the course of the trial. * Pregnant females or females who have given birth within the past 90 days prior screening or who are breastfeeding. * Women of childbearing potential unless using highly effective methods of contraception during dosing and for 15 weeks after stopping treatment * Significant bleeding disorder * Active HIV infection * Active Hepatitis B infection * Positive test for Hepatitis C RNA * Malignant disease * Active infection or immune deficiency