Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With No Reperfusion Therapy (INSIST-NRT)

Inclusion Criteria: 1. Age ≥18 years; 2. Major neurologic deficits: 6≤NIHSS≤20; 3. Missing recanalization therapy (IVT or EVT) or progressive stroke, which was defined as symptoms worsen in 48 hours (an increase in NIHSS more than 4); 4. Premorbid mRS 0 or 1; 5. Signed informed consent. Exclusion Criteria: 1. Modified Rankin Score \>2 caused by a history of prior stroke; 2. Patients who underwent intravenous thrombolysis or Endovascular treatment; 3. Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia （ \<80000/mm3; 4. Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis; 5. Severe hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg); 6. Unsuitable for this clinical studies assessed by researcher.