The Role of Statins in the Prevention of Contrast-induced Acute Kidney Injury in Patients With Cardiovascular Diseases

I.M. Sechenov First Moscow State Medical University150 enrolled

Overview

The aim of the study is to assess the role of statins and different dosage regimens in the prevention of contrast-induced acute kidney injury in patients with cardiovascular diseases requiring intravenous contrast media administration before computer tomography

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

150

Conditions

Contrast-induced Acute Kidney Injury Cardiovascular Diseases

Interventions

AtorvastatinDRUG

To compare the preventive role of low- and high-dose statin regimens in the prevention on contrast-induced acute kidney injury in statin-naive patients with cardiovascular diseases undergoing computer tomography with intravenous contrast media administration

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Written informed consent * Indications for computer tomography with intravenous contrast media administration * Cardiovascular diseases (arterial hypertension, arrhythmia etc) Exclusion Criteria: * Pregnancy * Statin therapy before inclusion in the study * Acute coronary syndromes * Contraindications for statins administration * Patients with chronic kidney disease stages 4-5 * Contraindications for computer tomography with contrast media administration * Nephrotoxic drugs use (NSAIDS, vancomycin etc)

Locations (1)

Sechenov University

Moscow, Russia

Outcomes

Primary Outcomes

Contrast-induced acute kidney injury

Contrast induced acute kidney injury is defined as the 25% rise (or 0,5 mg/dl) of serum creatinine from baseline assessed 48 hours after administration of contrast media.

Time frame: 48-72 hours after contrast media administration

Data from ClinicalTrials.gov

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