Biomarkers for Intestinal Permeability

University of Hohenheim51 enrolled

Overview

This study aims to find easy-to-measure biomarkers of intestinal permeability as surrogate markers for effortful "gold standard" methods.

This study aims to find easy-to-measure biomarkers of intestinal permeability as surrogate markers for effortful "gold standard" methods. In healthy volunteers potential biomarkers for intestinal permeability as well as an established "gold standard" method for intestinal permeability (urinary lactulose/mannitol excretion) will be measured at one time point. Using correlation analyses, potential associations will be assessed and potential biomarkers will be addressed and discussed.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Focus: Simplified Method to Assess Intestinal Permeability

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers * Written informed consent Exclusion Criteria: * Underweight (BMI \<18 kg / m2) and obesity from grade II (BMI ≥ 30 kg / m2) * Acute or chronic gastrointestinal diseases * Chronically consuming diseases (e.g. chronic tumor disease, florid infections, etc.) * Smokers (12 hours before the test and during the test it is not allowed to smoke) * Ingestion of intestinal therapeutics, antibiotics, immunosuppressants or similar within the last 3 months * Simultaneous participation in another clinical study * Pregnancy / breastfeeding * Intolerance to the sugar solution * Occurrence of relevant diseases * Revocation of consent

Locations (1)

University of Hohenheim

Stuttgart, Germany