Improving Neuroprotective Strategy for Ischemic Stroke With Sufficient Recanalization After Thrombectomy by Edaravone Dexborneol

Inclusion Criteria: 1. 18 to 80 years of age; 2. Patients who presented with acute ischemic stroke and a large vessel occlusion in the anterior circulation and met the criteria of mechanical thrombectomy; 3. Sufficient recanalization within 9 hours of stroke onset; 4. Sufficient recanalization （TICI 2b-3）; 5. Acute ischemic stroke with neurological baseline deficit equivalent to the National Institute of Health Stroke Scale (NIHSS) ≥ 6 before recanalization treatment; 6. First ever stroke or mRS≤1 after previous disease 7. The availability of informed consent. Exclusion Criteria: 1. Acute ischemic stroke patients with insufficient recanalization（TICI \< 2a） 2. Hemorrhagic transformation (PH2) indicated by NCCT performed after the operation immediately; 3. Hemorrhagic stroke: cerebral hemorrhage, subarachnoid hemorrhage; 4. Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia （ \<100000/mm3）; 5. Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis; 6. Severe hypertension (systolic blood pressure over 200mmHg or diastolic blood pressure over 110 mmHg); 7. Patients with malignant tumor or under antineoplastic therapy with estimated lifetime less than 3 months; 8. Pregnancy, plan to get pregnant or during lactation; 9. Patients with contraindication or allergic to any ingredient of drugs in our study; 10. Unsuitable for this clinical studies assessed by researcher.