This study focuses on the evaluation of various factors repeatedly discussed in relation to the impaired sedation of intubated ventilated COVID-19 patients. The sedation response of \>100 moderately to severely affected COVID-19 ARDS was evaluated. The sedation level was measured at the bedside using the Richmond Agitation and Sedation Scale and ventilator synchrony. The evaluation was performed according to the static evaluation plan with respect to age, storage therapy and organ failure.
Study Type
OBSERVATIONAL
Enrollment
114
None, solely treatment documentation
University Hospital Frankfurt
Frankfurt am Main, Hesse, Germany
Position therapy
Number of positioning therapys during treatment
Time frame: Data collection is performed at the date of death from any cause or discharge up to 10 weeks.
Agitation and sedation level
Measurement is performed using the Richmond Agitation and Sedation Scale (RASS, range: -5\[Unarousable\] to +4 \[Combative\], normal condition=0 \[Alert and calm\])
Time frame: 30 minutes after study enrolment
Agitation and sedation level
Change of sedation level using the Richmond Agitation and Sedation Scale (RASS, range: -5\[Unarousable\] to +4 \[Combative\], normal condition=0 \[Alert and calm\])
Time frame: Change in average dosage within 8 hours.
Application of opioid analgesic
Applied dosage of sufentanil (measured in µg/kg/h)
Time frame: 30 minutes after study enrolment
Change of application of opioid analgesic
Applied dosage of sufentanil (measured in µg/kg/h)
Time frame: Change in average dosage within 8 hours.
Application of opioid analgesic
Applied dosage of remifentanil (measured in µg/kg/min)
Time frame: 30 minutes after study enrolment
Change of application of opioid analgesic
Applied dosage of remifentanil (measured in µg/kg/min)
Time frame: Change in average dosage within 8 hours.
Application of sedative
Applied dosage of midazolam (measured in mg/kg/h)
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Time frame: 30 minutes after study enrolment
Change in sedative dosage applied
Applied dosage of midazolam (measured in mg/kg/h)
Time frame: Change in average dosage within 8 hours.
Application of sedative
Applied dosage of propofol (measured in mg/kg/h)
Time frame: 30 minutes after study enrolment
Change in sedative dosage applied
Applied dosage of propofol (measured in mg/kg/h)
Time frame: Change in average dosage within 8 hours.
Application of sedative
Applied dosage of lormetazepam (measured in mg/kg/min)
Time frame: 30 minutes after study enrolment
Change in sedative dosage applied
Applied dosage of lormetazepam (measured in mg/kg/min)
Time frame: Change in average dosage within 8 hours.
Application of sedative
Applied dosage of clonidine (measured in µg/kg/h)
Time frame: 30 minutes after study enrolment
Change in sedative dosage applied
Applied dosage of clonidine (measured in µg/kg/h)
Time frame: Change in average dosage within 8 hours.
Application of sedative
Applied dosage of Dexmethomidine (measured in µg/kg/h)
Time frame: 30 minutes after study enrolment
Change in sedative dosage applied
Applied dosage of Dexmethomidine (measured in µg/kg/h)
Time frame: Change in average dosage within 8 hours.
Application of sedative
Applied dosage of esketamine (measured in mg/kg/h)
Time frame: 30 minutes after study enrolment
Change in sedative dosage applied
Applied dosage of esketamine (measured in mg/kg/h)
Time frame: Change in average dosage within 8 hours.
Patient Characteristics
Age (in years)
Time frame: The data is recorded at the time of enrolment
Patient Characteristics
Height (in centimeters)
Time frame: The data is recorded at the time of enrolment
Patient Characteristics
Weight (in kilograms)
Time frame: The data is recorded at the time of enrolment
Need for renal replacement therapy
The necessity and application of a renal replacement procedure is documented
Time frame: Data collection is performed at the date of death from any cause or discharge up to 10 weeks.
Need for extracorporeal membrane oxygenation (vvECMO)
The necessity and application of an extracorporeal oxygenation procedure (ECMO) is documented
Time frame: Data collection is performed at the date of death from any cause or discharge up to 10 weeks.