The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on neural oscillations of individuals diagnosed with Down syndrome.
This study will compare the effect of tPBM to sham tPBM on gamma neural oscillations in the brain as assessed by EEG, and on language, attention and memory as assessed by neuropsychological testing. Participants will be randomized to either tPBM with near-infrared light (tPBM-NIR) or tPBM-Sham and will undergo 18 treatments (3 treatments per week for 6 weeks) in addition to baseline, short-term and long- term follow up visits.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
19
tPBM-NIR involves the use of a device that administers near-infrared light over the scalp. The light activates target brain regions.
tPBM-Sham involves the use of an identical device to tPBM-NIR but does not administer near-infrared light. It mimics the sensation by applying heat but does not actually activate target regions of the brain
Massachusetts General Hospital at the Charlestown Navy Yard
Charlestown, Massachusetts, United States
Change in EEG
Gamma Power (40 Hz) of EEG Signal
Time frame: Baseline to Post-Treatment (~6 weeks)
Change in Wordless Picture Book
Standardized narrative sampling tasks that measure intelligibility, vocabulary, syntax and grammar of language
Time frame: Baseline to Post-Treatment (~6 weeks)
Change in Cambridge Neuropsychological Test Automated Battery
Reaction Time, Paired Associative Learning, and Motor Screening Task subtests
Time frame: Baseline to Post-Treatment (~6 weeks)
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