This study is assessing the impact of timing of PD assessments on measures of platelet reactivity in patients undergoing PCI treated with cangrelor.
Cangrelor is characterized by reversible binding to the P2Y12 receptor and is promptly inactivated through dephosphorylation by ectonucleotidase leading to its very short plasma half-life. Consequently the timing at which PD assessments are performed after blood sample collection may impact measures of platelet reactivity in patients treated with cangrelor. We therefore hypothesize that measures of platelet inhibitory effects observed in cangrelor treated patients will reduce with time following blood sampling.
Study Type
OBSERVATIONAL
Enrollment
17
University of Florida
Jacksonville, Florida, United States
Change in platelet reactivity
measure of change platelet reactivity at time points
Time frame: wiithin 30 min, 1 hour, 2 hours, and 4 hours of blood sampling
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