Oral Health, Microbial Burden and COVID-19

Eastman Dental Insitute and Hospital150 enrolled

Overview

An observational study of patients with COVID-19 confirmed cases (with various degrees of severity) and controls. Oral and nasal swabs will be taken from 150 patients (50 with mild form and 50 with severe form of COVID-19 with or without mechanical ventilation, 50 healthy controls).

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Covid19 Periodontitis

Interventions

SwabOTHER

PCR test for SARS-CoV2, oral and nasal swab

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Must provide written informed consent 2. Subjects have to be tested (PCR) positive or negative for SARS-CoV2 infection 3. Must be able to provide oral and nasal swabbing within 48 hours of polymerise chain reaction (PCR) test results Exclusion Criteria: a. Under the age of 18 years old

Locations (1)

University College Hospital (UCH), UCL Eastman Dental Institute

London, United Kingdom

RECRUITING

Outcomes

Primary Outcomes

Oral microbial signature

To assess the oral microbial signatures that relates to SARS-CoV2 in patients with no, mild and severe disease.

Time frame: Day 1

Secondary Outcomes

Nasal microbial signature

To assess the nasal microbial signatures related to SARS-CoV2 in patients with no, mild and severe disease and to assess the role of the oral expression of ACE2-Ang II system during SARS-CoV2 in relation to disease outcome (mild, severe COVID).

Time frame: Day 1

Central Contacts

Jeanie Suvan

CONTACT

+442034561108 j.suvan@ucl.ac.uk

Data from ClinicalTrials.gov

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