Osteogenic Potential of Cissus Quadrangularis Alveolar Ridge Distraction

Al-Azhar University20 enrolled

Overview

Deficient alveolar mandibular ridge corrected distraction osteogenesis to facilitate dental implant placement. Patients grouped into 2 groups: one group received Cissus quadrangularis during the consolidation period, and the other group received placebo.

OPGs were taken immediately after distractor placement, at end of activation period, at 1st,2nd month of consolidation period, and at end of consolidation period. Change in bone height was evaluated immediately after distractor placement, at end of activation and end of consolidation periods. CBCT were taken immediately after implant installation, and 6 months later to evaluate change bone density and marginal bone level about the dental implant. histological evaluation was done by biopsy obtained, by trephine bur, from implant site during its preparation. The bone biopsy fixed in 4% formalin solution for 7 days, rinsed in water, and dehydrated in sequent phases of ethanol (70, 80, 90, and 100%) and then specimens were stained by hematoxylin- eosin for microscopic evaluation. Radiographic evaluation

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Distraction of Bone Dental Implant

Interventions

Cissus QuadrangularisDRUG

Drug with osteogenic potential given to the patients after consolidation period. dose was two capsules once /day with meals for 6 weeks

Eligibility

Sex: ALLMin age: 30 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients were included if they were free from any disease that may affect healing. Also, presented with 2-3 missing teeth at least in posterior area and CBCT showed bone height above inferior alveolar canal (IAC) ranged 8-10mm. Exclusion Criteria: * patients were excluded if they suffered from any disease affect tissue healing, bad oral hygiene or heavy smoking patients

Locations (1)

Faculty of dental medicine

Cairo, Nasr City, Egypt

Outcomes

Primary Outcomes

Bone gain after distraction

Increase in bone height after distraction

Time frame: immediately at end of distractor activation

Relapse after distraction

Relapse evaluated on panorama

Time frame: 3 months from beginning of consolidation period

Crestal bone loss around dental implant

By using cone beam CT, crestal bone level around implant evaluated by measuring a distance from implant apex to a point on dental implant where bone contacts the dental implant mesially and distally. then average of bone loss round each implant was obtained.

Time frame: 6 months from implant placement

Bone density around dental implant

By using cone beam CT, bone density assessed around dental implant at crestal, middle, and apical portions then average was obtained

Time frame: 6 months from implant placement

Data from ClinicalTrials.gov

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