Assessment of the Pharmacodynamic and Pharmacokinetic Interaction of Remimazolam and Remifentanil

Inclusion Criteria: * Healthy male or female adults ≥18 to ≤70 years old * American Society of Anesthesiologists (ASA) Physical Status 1 * Body mass index (BMI) \>18 to \<30 kg/m2 * Bilateral patent a. radialis * For female volunteers of childbearing potential: Negative results of 2 pregnancy tests, the first test taken at the start of Screening and the second test taken from the morning urine within 3 hours before the start of the administration of the IMP as well as consent to use highly effective birth control from the last menstrual cycle prior to the start of the IMP until the end of the trial follow-up procedures. Highly effective methods of birth control include: * Combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation (oral/intravaginal/transdermal) * Progestogen-only hormonal contraception associated with inhibition of ovulation (oral/injectable/implantable) * Intrauterine device (IUD) * Intrauterine hormone-releasing system (IUS) * Bilateral tubal occlusion * Vasectomised partner (provided that the partner is the sole sexual partner of the female patient of childbearing potential and that the vasectomised partner has received medical assessment of the surgical success). * Sexual abstinence Women who had their last menstruation at least two years ago or who underwent surgical interventions (surgical birth control, bilateral oophorectomy, hysterectomy, etc.) are regarded as having no childbearing potential. * For male participants, their partner must not become pregnant during the trial. They should inform their partner about this. They must also agree to use of barrier methods of contraception during the trial. * Subject agrees not to use alcohol for 2 days, not to use nicotine for 1 week, and not to use recreational drugs for 2 weeks prior to the first period until End of Trial * Understanding of the trial procedures and be willing to follow the instructions of the Investigator or centre staff during the course of the clinical trial * Written informed consent obtained from the subject Exclusion Criteria: * Known intolerance to benzodiazepines, flumazenil, opioids or any ingredients of the remimazolam drug products (e.g., dextran, lactose) * Pregnancy, or currently breastfeeding * Have current neurological disorder(s) (epilepsy, the presence of a brain tumour, a history of brain surgery, hydrocephalic disorders, depression needing treatment with anti-depressive drugs, a history of brain trauma, a subarachnoidal bleeding, TIA or cerebral infarct, psychosis or dementia, schizophrenia, alcohol or drug abuse). * Have a disease(s) involving the cardiovascular system (hypertension, coronary artery disease, prior acute myocardial infarction, any valvular and/or myocardial disease involving decrease in ejection fraction, arrhythmias, which are either symptomatic or require continuous medication/pacemaker/automatic internal cardioverter defibrillator) * Recent (\<3 months) use of psycho-active medication (benzodiazepines, anti-epileptic drugs, Parkinson's medication, neuroleptics, anxiolytics, anti-depressant drugs, and opioid analgesics) * A history of illicit drug or alcohol abuse within two years prior to screening * Any ongoing condition considered by the Investigator as potentially relevant to the trial * Any medical history considered by the Investigator as potentially relevant to the trial * An employee or direct relative of an employee of the trial site, the CRO or the Sponsor. * Resting HR \<45 bpm or ≥90 bpm OR resting SABP \<90 mmHg or ≥140 mmHg OR resting DABP \<50 mmHg or ≥90 mmHg, except for those cases where hypertension is accompanied by tachycardia as judged by the screening physician. * Positive urine drug screening test (amphetamines, methamphetamines, benzodiazepines, barbiturates, marijuana, cocaine, and opioids). * Positive Covid-19 screening test * Any participant as judged by the PI or Sub-Investigator to be inappropriate for the trial for any other reason * Clinically significant, as judged by the Investigator abnormal ECG * Clinically significant abnormal laboratory values * Participation in a clinical trial of an Investigational Drug or Medical Device within three months prior to the Screening Visit * Blood donation of ≥500mL within three months prior to Screening Visit * Prior participation in this clinical trial. However, non-dosed drop-outs can participate in the trial again but will need to be re-screened.