Single and Multiple Ascending Dose Study of CORT125329 in Healthy Participants

Inclusion Criteria: * Body mass index of 18.0 to 30.0 kg/m\^2 * Weight of ≤102 kg * Must agree to adhere to the contraception requirements * Additional criteria apply. Exclusion Criteria: * Received any investigational medicinal product in a clinical research study within the 90 days * History of any drug or alcohol abuse in the past 2 years * Regular alcohol consumption * Current smokers and those who have smoked within the last 6 months * Current users of e-cigarettes and nicotine replacement products and those who have used these products within the last 6 months * Females of childbearing potential including those who are pregnant or lactating (all female subjects must have a negative pregnancy test at screening and admission) * Clinically significant abnormal clinical chemistry, haematology or urinalysis as judged by the Investigator * Confirmed positive drugs of abuse test result * Positive hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV Ab) or human immunodeficiency virus (HIV) results * Active renal and/or hepatic disease * History of clinically significant cardiovascular, renal, hepatic, endocrine, metabolic, respiratory, GI, neurological or psychiatric disorder, as judged by the Investigator * Any form of cancer within the last 5 years (exceptions apply) * History and/or symptoms of adrenal insufficiency * History of clinically significant gastrointestinal disease * Has a condition that could be aggravated by glucocorticoid antagonism * Serious adverse reaction or serious hypersensitivity to any drug or the formulation excipients * Presence or history of clinically significant allergy requiring treatment * Donation or loss of greater than 400 mL of blood or plasma within the previous 3 months * Are taking, or have taken, any prescribed, over-the-counter drug (other than 4 g per day paracetamol), vitamins or herbal remedies within 14 days before the study (exceptions may apply on a case by case basis) * Are currently using glucocorticoids or have a history of systemic glucocorticoid use at any dose within the last 12 months or 3 months for inhaled products * Additional criteria apply.