Cytometric Immunodiagnostics of Latent Tuberculosis Infection (LTBI)

Thomayer University Hospital120 enrolled

Overview

TB-reactive immune cells will be tested in a multiparametric flow cytometry to distinguish an immune response for antigens of Mycobacterium spp. in TB disease/latent infection or a reaction after BCG vaccine.

The goal of this project is the verification of current cytometric panel of detection antibodies in a wider panel of stimulative immunodominant antigens for CD4+ and CD8+ T cells in combination with adjuvants 2 in a in vitro activating test.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

LTBI BCG Vaccination Reaction TB

Interventions

Blood drawDIAGNOSTIC_TEST

Blood draw and the analysis of blood in laboratory

Eligibility

Sex: ALLMin age: 4 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: active TB, contact with TB infection in previous 3 months before the study \- Exclusion Criteria: * HIV positive patients

Locations (2)

Faculty of Science

Prague, Czechia

RECRUITING

Thomayer Hospital

Prague, Czechia

RECRUITING

Outcomes

Primary Outcomes

Peer-review publication of results of our study

Time frame: 2 years

Secondary Outcomes

Creation of new diagnostic tool and his comparision with existing IGRA test (QTF-GP and TST)

Time frame: 2 years

Central Contacts

Petra Hadlová, MGR

CONTACT

+724077200 Petra.hadlova@natur.cuni.cz

Karolína Doležalová, MD

CONTACT

+420777246841 karolina.dolezalova@ftn.cz

Data from ClinicalTrials.gov

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