A Prospective Study of Application of Platelet Mapping in Chronic Liver Disease Complicated With ALI and/or AD in China

Inclusion Criteria: 1. chronic liver disease: including chronic liver hepatitis patients without cirrhosis, compensated cirrhosis patients, decompensated cirrhosis patients and non-alcoholic fatty liver disease patients. 2. ALI(acute liver injury): including \[ALT \> 3 ULN(upper limited of normal),AST \> 3 ULN or TB \> 2 ULN within 1 week before enrollment\] or AD(acute decompensation) : including \[(having ascites, hepatic encephalopathy and/or bacterial infection within 1 month before enrollment)\]. Exclusion Criteria: 1. those who had hepatocellular carcinoma or other types of malignancies; 2. obstructive biliary diseases or other disease lead to bilirubin evaluation; 3. those who had acute hemorrhage one week before admission 4. those who received platelet, cryo transfusion or plasmapheresis one week before admission 5. pregnancy and breastfeeding 6. those who received liver transplantation or kidney transplantation; 7. combine with other disease lead to organ failure including heart failure (NYHA IV),respiratory failure（PaO2\<60mmHg),renal insufficiency(CKD 5) and conscious disturbance (GCS\<8) 8. readmission; 9. death within 24 hours.