This study concerns the creation of a biological collection (blood samples) in patients with Epithelial Ovarian Cancer in in order to describe the immune response with PARP inhibitors.
The aim is to assess the impact of anti-PARP on peripheral immune populations and the amount of DNA circulating; to correlate these data with tumor infiltration, with the initial clinical characteristics and with the clinical course; compare the immunogenic effect of different anti-PARPs.
Study Type
OBSERVATIONAL
Enrollment
50
Blood sampling during PARP inhibitor therapy
CHRU Jean Minjoz
Besançon, France
Centre Georges Francois Leclerc
Dijon, France
Immune response in plasma
Realization of a plasma library
Time frame: From date of inclusion until the date of first documented progression or date of death from any cause assessed up to 24 months
Immune response in PBMC
Realization of a PBMC bank
Time frame: From date of inclusion until the date of first documented progression or date of death from any cause assessed up to 24 months
Immune response in tumor DNA
Realization of a circulating tumor DNA bank
Time frame: From date of inclusion until the date of first documented progression or date of death from any cause assessed up to 24 months
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