The Effects of Inhaled Budesonide-formoterol-glycopyrronium in Moderate-to-severe COPD

Inclusion Criteria: * With capability of communicating via oral conversation or written documents and signing informed consent. * With capability of receiving and participating in study related auxiliary examinations. * Age: 40-80 yrs, both male and female, with or without smoking history, receiving treatment in community hospitals or outpatient department in general hospitals * GOLD Stage II-III COPD: FEV1/FVC\<70% and FEV1 45-80% predicted (about 1/3 subjects in 45%-50%), measured 20min after 400μg salbutamol inhalation * With stable COPD (no COPD exacerbation during the latest 4 weeks prior to the recruitment) and irregular use of inhalation therapy, or regular use of inhalation therapy but no more than 2 weeks. Subject is willing and, in the opinion of the investigator, able to adjust current COPD therapy, as required by the protocol. Exclusion Criteria: * Subjects are participating in other clinical research or have completed another clinical research within 3 months prior to screening. * Significant diseases or conditions other than COPD. A significant disease or condition is defined as a disease or condition which, in the opinion of the investigator, may put the patient at risk because of participation in the study or may influence either the results of the study or the patients' ability to participate in the study * Patients with clinical diagnosis of lung cancer, bronchiectasis, pneumoconiosis, or other single restricted ventilation. * Severe cardiovascular, neural, hepatic, renal and hematologic diseases or malignancies that may interfere with the operation of the study. * Patients with prostatic hyperplasia or bladder neck obstruction with significant symptoms, or narrow angle glaucoma * Patients have a current and history diagnosis of asthma, or who have a blood eosinophil count ≥600/mm3 (0.6×109/L). * Patients with active pulmonary tuberculosis * Patients with life-threatening pulmonary embolism, α1-antitrypsin deficiency, or cystic fibrosis * History of pneumonectomy. * COPD exacerbation in 4 weeks prior to the first visit (V1), or hospitalization and/or antibiotic application and/or oral or intravenous glucocorticosteroids application is required during screening stage. * Long-term oxygen therapy, frequent use of glucocorticosteroids orally or intravenously (prednisone\>10mg/d), or long-term use of antibiotics. * Women who are pregnant or lactating or are planning to become pregnant during the course of the study, or women of childbearing potential who are not using an acceptable method of contraception. * Planned hospitalization or blood donation during the trial. * Known hypersensitivity or intolerance to trial drugs. * History of chronic alcohol or drug abuse, or any other conditions that may impact compliance. * With contraindications to undergo bronchoscopy.