Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene Therapy

Inclusion Criteria: Provision of written informed consent for this study by subjects or as applicable parent legal guardian. Treated with drug product for therapy of premature ovarian insufficiency in a Institute Bio-Stem Cell Rehabilitation UAB clinical study. Diagnosed of premature ovarian insufficiency ESHRE: * Women age of 18 to 40 years * Have experienced 4 months of oligo/amenorrhea * Two serum follicle-stimulating hormone (FSH was \>40 mIU/ml levels in the menopausal range, obtained at least a month apart * lower FSH levels ( 25 mIU/ml) * anti-Müllerian hormone (AMH) serum levels ( 3.0 ng/ml) Exclusion Criteria: There are no exclusion criteria for this study