The purpose of this study is to prospectively analyze changes in macular pigment optical density and dermal carotenoid levels as they relate to visual field function in patients prescribed a macular pigment-containing medical food (Lumega-Z), in combination with a topical carbonic anhydrase inhibitor.
This is a prospective double-masked, randomized controlled trial which evaluates central visual field function as it relates to macular pigment optical density, contrast sensitivity, and dermal carotenoid levels in the presence of a commercial macular pigment-containing medical food (Lumega-Z). Participants will be randomized to twelve weeks of supplement + dorzolamide or twelve weeks of placebo. All packaging of supplement and dorzolamide and the placebo will be identical and distributed by a third party. Both subjects and the investigators examining patients will be masked to placebo and experimental group assignment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Ophtalmology Clinic of William E Sponsel
San Antonio, Texas, United States
Pericentral Visual Function
Mean deviation and pattern standard deviation of 10-2 Humphrey visual field
Time frame: 3 Months
Macular Pigment Optical Density
Macular Pigment Optical Density measured by Mapcat SF
Time frame: Monthly for 3 months
Dermal Carotenoid Levels
Measured by Veggie Meter
Time frame: Monthly for 3 months
Contrast Sensitivity
Measured by Vector Vision CSV-2000
Time frame: Monthly for 3 months
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