The Safety and Efficacy of Fluoxetine for Refractory Primary Mono-symptomatic Nocturnal Enuresis in Children

Inclusion Criteria: * Primary Monosymptomatic nocturnal enuresis * Failed treatment with desmopressin. * The enuresis alarm had either been tried without effect, or deemed unfeasible because of the family situation. * All patients had either tried and failed combination therapy with anticholinergics or, because of contraindications, been unable to receive such therapy. * Severe enuresis with at least seven wet nights out of 14 Exclusion Criteria: * Underlying renal, urologic, neurologic, endocrinologic, or cardiac conditions * Depression * Severe psychiatric diseases * Untreated constipation