viTAmin K2 and rEcOVery From ExeRcise

University of Glasgow80 enrolled

Overview

The aim of the current study, therefore, is to investigate the effects of vitamin K2 supplementation on the physiological responses to an acute bout of resistance exercise.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Inflammation Oxidative Stress Vitamin K Exercise Strength Recovery

Interventions

Vitamin K2DIETARY_SUPPLEMENT

Vitamin K2

Micro-crystalline celluloseDIETARY_SUPPLEMENT

Micro-crystalline cellulose

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Participant is able and willing to sign the Informed Consent From * No plans to change lifestyle (activity and nutrition) during the study period * Older group (n=40): 65 years of age or older. * Younger group (n=40): Aged 18-40 years Exclusion Criteria: * Not currently, or in the last year, participating in more than 1h per week of vigorous aerobic physical activity or any resistance exercise * BMI \> 30 kg/m2 * diabetes * severe cardiovascular disease * seizure disorders * liver disease * uncontrolled hypertension (\>150/90mmHg at baseline measurement) * cancer or cancer that has been in remission \<5 years * ambulatory impairments which would limit ability to perform assessments of muscle function * dementia * currently taking Vitamin K2 supplements * currently taking Vitamin K antagonists/anticoagulants (e.g. warfarin) * current smoking * history of drug abuse * taking medication known to affect muscle (e.g. steroids).

Locations (2)

University of Glasgow

Glasgow, United Kingdom

Stuart Robert Gray

Glasgow, United Kingdom

Outcomes

Primary Outcomes

Change in post exercise recovery of muscle strength

Muscle strength (MVC) of the knee extensor muscles will be measured before and after (3h, 24h, 48h, 72h) an acute bout of resistance exercise