Delayed neurocognitive recovery is defined as a cognitive decline arising after surgery. In the present study, the authors evaluate the level of D-Amino Acid Oxidase, D-serine and Serine racemase in blood as an indicator of delayed neurocognitive recovery after cardiac surgery.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
82
Blood sampling is done before surgery and at 1, 2, and 7 day after surgery. The level of D-Amino Acid Oxidase, D-serine and Serine in blood are assessed.
Neurocognitive test is performed before surgery and at 7 day after surgery
Postoperative delirium is assessed daily during 7 days after surgery.
SMG-SNU Boramae Medical Center
Seoul, Select State/Province, South Korea
Change of concentration of D-Amino Acid Oxidase in blood at 1, 2, and 7 day after surgery
Blood level of D-Amino Acid Oxidase is assessed.
Time frame: Before surgery and at 1, 2, and 7 day after surgery
Concentration of D-serine in blood
Blood level of D-serine is assessed.
Time frame: Before surgery and at 1, 2, and 7 day after surgery
Concentration of Serine racemase in blood
Blood level of Serine is assessed.
Time frame: Before surgery and at 1, 2, and 7 day after surgery
Occurrence of delayed neurocognitive recovery
Neurocognitive assessment
Time frame: Before surgery and at 7 day after surgery
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