Treatment of Angiotensin Converting Enzyme Inhibitor-induced Angioedema

Inclusion Criteria: * Males and females 18 years of age or older * Must currently be on ACE inhibitor therapy and have received a dose within 36 hours * Presenting with moderate to severe angioedema affecting the upper aerodigestive tract (face, lips, cheeks, tongue, soft palate/uvula, pharynx, and larynx). The severity of the angioedema attack will be determined by the subject's worst severity rating at baseline among 4 clinical domains (difficulty breathing, difficulty swallowing, voice changes, and tongue swelling) based on a clinically validated angioedema severity scale29 (Table) * Presenting with ACE inhibitor-induced angioedema within 12 hours after onset * All females must have a locally obtained negative pregnancy test prior to administration of the study drug. Those who have had a total hysterectomy, bilateral oophorectomy, or are two years post-menopausal do not require a pregnancy test. * Must be able to provide written informed consent to participate in the study to fulfill all study requirements Exclusion Criteria: * Pregnancy and/or breast feeding * Patients with angioedema that is likely due to causes other than ACE inhibitors, including hereditary angioedema, acquired angioedema, and allergic angioedema (food, insect bite or sting with clear response to anti-allergy medications) * Patients exhibiting acute urticaria * Evident clinical response to glucocorticoids, antihistamines, or epinephrine * A family history of recurrent angioedema * Documented intolerance to plasma * Documented congenital deficiency of immunoglobulin A in the presence of anti-immunoglobulin A antibodies * Patients with heart failure of the severity that precludes safe transfusion of High ACE activity plasma * Patients with acute pulmonary edema * Patients with morbid obesity as defined by BMI\>40; morbidly obese patients have a higher volume of blood needing higher amounts of plasma and therefore will be excluded from this pilot study * Opinion of the investigator that the patient would not be a good candidate * Participation in a clinical study in the past 30 days