Non-Invasive Brain Stimulation to Control Large-Scale Brain Networks

University of Minnesota9 enrolled

Overview

This project will assess the feasibility of traveling wave transcranial alternating current stimulation (tACS) to modify working memory performance and large-scale brain connectivity in surgical epilepsy patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Working Memory

Interventions

Transcranial alternating current stimulationDEVICE

Traveling wave transcranial alternating current stimulation will be applied at 4 Hz and 23 Hz over frontal and parietal brain areas in a randomized counterbalanced order.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. the patient can consent for themselves; 2. the patient has or is scheduled for surgically implanted electrodes for the purposes of phase II epilepsy surgical evaluation; 3. age 18+ years old; Exclusion Criteria: 1\. diminished capacity to consent;

Locations (1)

University of Minnesota

Minneapolis, Minnesota, United States

Outcomes

Primary Outcomes

Electrophysiological outcomes

Changes in spectral power and coherence of the local field potentials during transcranial electric stimulation relative to no stimulation periods.

Time frame: Immediate effect during stimulation

Working memory outcomes

Changes in working memory performance as measured with the N-back task (quantified with d-prime) during stimulation.

Time frame: Immediate effect during stimulation

Data from ClinicalTrials.gov

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