Transcriptomic Landscape of T Lymphocytes of Atopic Dermatitis, Atopic Prurigo Nodularis (of Besnier) and Non-atopic Prurigo Nodularis (of Hyde) Using Single Cell RNA-sequencing

Inclusion Criteria: * More than 18 years of age * Signature of the written contentment * Clinical diagnostic of PN defined by the following: a minimum of 20 PN lesions, in total on both legs, and/or both arms; an average worst itch score of ≥7. Atopic PN will be defined as PN associating clinical sings or history of AD according to Hanifin et Rajka criteria. Non-Atopic PN will be defined as PN non-associated with clinical sings or history of AD according to Hanifin et Rajka criteria. * or confirmed diagnosis of AD according to Hanifin et Rajka criteria without associated PN. * Washout period for topical treatments (\> 1 week) ans systemic treatments (\> 1 month). * Indication and absence of contraindication to performing a skin biopsy as part of the treatment Inclusion criteria for healthy controls: * more than 18 years of age * Signature of the written contentment * Hospitalised in the plastic surgery department of Saint-Louis Hospital. * No associated inflammatory or tumoral skin condition * No contraindication for biopsy Exclusion criteria : * Presence of inflammatory or tumoral skin morbidities other than PN and atopic dermatitis * Treatment induced pruritus * Pruritus secondary to other medical conditions such as bullous dermatosis, renal insufficiency, infectious diseases, …) * AD under biologic therapy * Patient under guardianship or conservatorship * No health insurance coverage * Patient under State Medical Assistance (AME) * Pregnancy or breastfeeding * Persons deprived of their liberty by a judicial or administrative decision * People undergoing psychiatric care making their consent impossible * Adults who are the subject of a legal protection measure or unable to express their consent * Patients unable to read and write Exclusion criteria for healthy controls: * Inflammatory or tumoral medical condition * Biological therapy for any other medical condition * Associated inflammatory or tumoral skin condition * Pregnancy or breastfeeding * Persons deprived of their liberty by a judicial or administrative decision * People undergoing psychiatric care making their consent impossible * Adults who are the subject of a legal protection measure or unable to express their consent * Patients unable to read and write