Explorative study to investigate potential predictors of myocardial injury, acute kidney injury and pulmonary disorder after acute high-risk abdominal surgery.
The main issues are: * To investigate if coronary calcification predisposes the development of myocardial injury and causes an increased mortality rate. * To evaluate the predictive value of NT-pro-BNP in relation to the development of MINS and the mortality rate. * To evaluate the predictive value of different biomarkers of AKI in relation to which patients develop AKI. * To examine the proteins, exosomes and single cell RNA during acute kidney injury in order to describe the molecular processes in the kidney during AKI. * To examine whether a chest CT scan without contrast enhancement will change treatment decisions in the acute gastrointestinal patient compared with a chest x-ray.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
600
Chest CT without contrast enhancement and chest X-ray as supplement to diagnostic abdominal CT
Nordsjaellands Hospital
Hillerød, Denmark
Proportion of patients with myocardial injury af non-cardiac surgery
Troponin-I above specified level and dynamic changes
Time frame: 30 days
Mortality rate
Postoperative mortality
Time frame: 30 days
Mortality rate
Postoperative mortality
Time frame: 90 days
Mortality rate
Postoperative mortality
Time frame: 1 year
Acute kidney Injury
According to KIDGO criteria
Time frame: 30 days
Proportion of patients with pulmonary pathology
Findings (including incidental) on a chest x-ray and chest CT scan without contrast enhancement
Time frame: 1 day
Proportion of patients with pulmonary complications
Postoperative complications
Time frame: 30 days
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