Vitamin C (ascorbic acid) is a water-soluble vitamin having anti-inflammatory, immunomodulatory, anti-oxidative, antithrombotic and antiviral properties. Considering these effects vitamin C should have beneficial impact in patients suffering from sepsis and acute respiratory distress syndrome (ARDS). The current study is designed to assess the beneficial effects of Vitamin C in COVID-19 infected patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
278
mega dose is given to the selected critically ill patients
Bahria Town International Hospital
Lahore, Punjab Province, Pakistan
Partial pressure of Oxygen in arterial blood to fraction of inspired Oxygen (P/F ratio)
Time frame: 1 and 4th day
Survival analysis
Time frame: 28 days follow up
Length of Hospital stay
Time frame: Admission to discharge
Need for intubation
number of intubations needed in both groups.
Time frame: 28 days
Inflammatory markers
comparison of the inflammatory markers, CRP, D.Dimer, Procalcitonin, LDH, TLC and hematological variables at day four after the intervention started.
Time frame: before the start of treatment (day 1) and on day 4
APACHE II score
Time frame: before the start of treatment (day 1) and on day 4
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.