This study aim to determine whether a small-dose esketamine infusion can be used for pain control in severe burn patients, and thereby reduce the total intra-operative opioid requirement. Secondary objectives are to determine whether this low-dose esketamine infusion will increase the stability of circulation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
26
Esketamine is infused through the whole period of surgery. Participants randomized to the esketamine arm will receive 1 mg/ml solution infused at 0.1 mg/kg/hour (0.1 ml/kg/h) .
Participants randomized to the placebo arm will receive 0.9 mg/ml sodium chloride, infused at a rate of 0.1 ml/kg/hour throughout the surgery.
2nd affiliated hospital, School of Medicine, Zhejiang Universtiy, China
Hangzhou, Zhejiang, China
RECRUITINGIntraoperative sufentanil
For all participants, the dose of intraoperative sufentanil will be recorded in micrograms and compared between the two arms.
Time frame: 24 hours
Intraoperative blood pressure
For all participants, blood pressure will be recorded and compared between the two arms.
Time frame: 24 hours
Intraoperative heart rate
For all participants, heart rate will be recorded and compared between the two arms.
Time frame: 24 hours
Intraoperative cardiac index
For all participants, cardiac index will be recorded and compared between the two arms.
Time frame: 24 hours
Post-operative recovery time
For all participants, the recovery time of spontaneous breathing will be recorded.
Time frame: 24 hours
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