Intraoperative Norepinephrine Versus Fresh Frozen Plasma in Patients Undergoing HIPEC to Reduce Renal Insult

National Cancer Institute, Egypt60 enrolled

Overview

comparing the effect of low dose norepinephrine infusion versus fresh frozen plasma in patients undergoing HIPEC to reduce renal insult

To compare the efficacy of maintaining intraoperative hemodynamic stability through infusing low dose norepinephrine versus fresh frozen plasma in patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy in cancer patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Anesthesia

Interventions

NorepinephrineDRUG

5 mic/kg/hr norepinephrine

Fresh frozen plasmaBIOLOGICAL

early administration of fresh frozen plasma

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I and II * World Health Performance Status ≤2 * scheduled for CRS/HIPEC operations Exclusion Criteria: * patient's refusal * allergy to any of the used drugs * impaired renal or liver functions

Locations (1)

Walaa Y Elsabeeny

Cairo, Egypt

Outcomes

Primary Outcomes

Renal insult

Creatinine level increase 0.3 mg/dl above preoperative baseline

Time frame: 24 hours

Data from ClinicalTrials.gov

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