Hyperglycemia in Patients With Takotsubo Syndrome

University of Campania Luigi Vanvitelli40 enrolled

Overview

Patients with Takotsubo cardiomiopathy (TTC) have over-inflammation and over-sympathetic tone. However, these conditions could cause higher rate of heart failure (HF) events and deaths at 2 years of follow-up. Conversely, hyperglycemia vs. normoglycemia could result in over expression of inflammatory markers and catecholamines thta could result in higher rate of HF and deaths at 2 years of follow-up in TTC patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Takotsubo Cardiomyopathy

Interventions

To report number of HF events and deathsOTHER

In these two cohorts of study authors will evaluate at 2 years of follow-up the number of HF events and of deaths.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * acute onset of a cardiovascular event, usually associated with substernal chest pain, initially regarded as STEMI/evolving coronary syndrome; * cardiac biomarker modifications (creatine kinase-MB and troponin I); * systolic dysfunction, predominantly characterized by akinesia/hypokinesia of the mid-to-distal portion of the left ventricle (LV) chamber, with hyper-contractile basal LV. Exclusion Criteria: * patients with previous previous myocardial infarction; * patients with previous TTC event; * patients affected by chronic kidney, liver, and cerebrovascular diseases.

Locations (1)

Raffaele Marfella

Naples, Italy

Outcomes

Primary Outcomes

The number of HF events

To evaluate the number of HF events by clinical visits, telephonic interviews and hospital discharge schedules.

Time frame: 12 months

Data from ClinicalTrials.gov

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