Modified CD19 CAR-T in Patients With Relapsed or Refractory CD19+ B-cell Malignancies

Inclusion Criteria: 1. Male or female aged 18-70 years; 2. Estimated survival time ≥ 12 weeks; 3. Histologically confirmed diagnosis of CD19+ B-ALL or CD19+ B-NHL(meeting one of the following conditions): 1. Ineffectively or relapses after 2 or more remedial treatments 2. Relapse after auto-HSCT or unsuitable for auto-HSCT; 4. At least one assessable tumor lesion; 5. ECOG performance status 0 to 2; 6. Creatinine clearance rate≥ 60 ml/min, ALT and AST ≤ 2.5 times of upper limit of normal, total bilirubin ≤ 1.5 times of upper limit of normal; 7. Male and female of reproductive potential must agree to use birth control during the study and for at least 30 days post study; 8. Patients or their legal guardians volunteer to participate in the study and sign the informed consent. Exclusion Criteria: 1. Patients with other uncontrolled malignancies; 2. Previously treated with any CAR-T cell product or other genetically-modified T cell therapy; 3. Patients with HIV infection, hepatitis B (HBsAg positive) or hepatitis C（anti-HCV positive); 4. Patients with central nervous system involvement by lymphoma ,malignant cells in cerebrospinal fluid or history of brain metastasis; 5. Patients with atrial or ventricular involvement by B-cell malignancies; 6. Patients with tumor mass require urgent treatment, such as ileus or vascular compression; 7. Patients with severe disease or other uncontrolled diseases that were not suitable for this trial, such as coronary heart disease, angina pectoris, myocardial infarction, arrhythmia, cerebral thrombosis, cerebral hemorrhage, grade 2-3 hypertension; 8. Unstable pulmonary embolism, deep venous embolism, or other major arterial/venous thromboembolism events occurred within 30 days prior to randomization. If patients receive anticoagulant therapy, the treatment dose must be stable prior to randomization; 9. Any situations that the investigators believes were not suitable for this trial; 10. Long-term use of immunosuppressive agents after organ transplantation, except for the patients recently or currently receiving inhaled steroids; 11. Pregnant(or lactation) women; 12. Patients with severe active infections(excluding simple urinary tract infection and bacterial pharyngitis)within 30 days prior to randomization