BMS-986325 in Healthy Participants and Participants With Primary Sjögren's Syndrome

Inclusion Criteria: Healthy Participants (Part A and Part B) * Healthy male and female participants as determined by no clinically significant deviation from normal in medical history, physical examination (PE), electrocardiograms (ECGs), and clinical laboratory determinations * Males and Females, ages 18, or local age of majority, to 50 years, inclusive at screening * Body mass index (BMI):18.0 to 30.0 kg/m2, weight: ≥ 50 kg at screening * Must be fully vaccinated against SARS-CoV-2 Participants with Sjögren's Syndrome (Part C) * Sjögren's syndrome in the absence of another immune-mediated disease or rheumatologic condition based on the 2016 American College of Rheumatology-European League Against Rheumatism (EULAR) Classification Criteria for primary Sjögren's syndrome (pSS). Historical diagnosis as pSS documented in medical records, using the 2016 ACR/EULAR criteria, is also acceptable * Seropositive for anti-Sjögren's syndrome antigen A antibody (anti-SSA). Previous anti-SSA are also acceptable, and results should be documented in the Case Report Form (CRF) as past medical history * Males and females, ages 18, or local age of majority, to 75 years, inclusive at screening * Body mass index (BMI): 18.0 to 35.0 kg/m2; weight ≥ 50 kg at screening * Must be fully vaccinated against SARS-CoV-2 according to local regulations Exclusion Criteria: Healthy Participants (Part A and Part B) - Any significant acute or chronic medical illness Healthy Participants (Part A and Part B) and Participants with Primary Sjögren's Syndrome (pSS) (Part C) \- Any major surgery within 4 weeks prior to study drug administration, or any surgery planned during the course of the study Other protocol-defined inclusion/exclusion criteria apply