Anti-ageing Efficacy of a Cosmetic Formulation Containing NMN (2%) Versus Placebo

Seneque SA89 enrolled

Overview

The study aims at evaluating skin wrinkling, puffiness and fatigue and dark circle appearance on asian and african-american healthy volunteer cohorts receiving a cosmetic formulation containing NMN (2%). The product will be evaluated after 28 and 56 days of twice-daily application in comparison with a reference cosmetic formulation using clinical scoring under dermatological control. Cosmetic acceptability and future use will also be subjectively evaluated by analysis of the subjects answers to an evaluation questionnaire.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Wrinkle Fatigue Puffiness Around the Eyes

Interventions

Test product cremeOTHER

twice daily application of creme containing 2% NMN

Reference cremeOTHER

twice daily application of reference creme

Eligibility

Sex: FEMALEMin age: 40 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy subject * Subject having given her free informed, written consent * Subject willing to adhere to the protocol and study procedures * Subject with normal frontal temperature lower than 37.5°c/100.4°F * Subject has read and understood the information given by the investigator related to protection against Novel Coronavirus 19 and necessity to contact the investigator in case of any suspicion of COVID related manifestation (increase of frontal temperature, cough, sore muscles, weakness…) during the study Exclusion Criteria: * Pregnant or nursing woman or woman planning to get pregnant during the study * Start, stop or change in hormonal treatment (including contraceptive pill) \<1.5 months * Cutaneous pathology on the study zone (face) * Use of topical or systemic treatment during the previous weeks liable to interfere with the assessment of the cutaneous efficacy of the study product * Subject having undergone a surgery under general anesthesia within the previous month * Know allergy to certain cosmetic or dermato-pharmaceutic products * Subject having done injections on face and/or a lifting * Excessive exposure to sunlight or UV-rays within the month preceding the study

Locations (2)

Eurofins CRL Cosmetics Inc

Piscataway, New Jersey, United States

Eurofins China

Guangzhou, China

Outcomes

Primary Outcomes

Wrinkles

clinical grading under dermatological control using 1) a 7 points Visual scale of Bazin from absence (0) to pronounced wrinkles (6) for the Asian panel and 2) a 5 points Visual scale of Bazin from absence (0) to pronounced wrinkles (4) for the Afro-American panel

Time frame: Change from baseline (day 0) at days 28 and 56 of application

Eye bags

clinical grading under dermatological control using 1) a 7 points Visual scale of Bazin from absence (0) to pronounced bags (6) for the Asian panel and 2) a 6 points Visual scale of Bazin from absence (0) to pronounced bags (5) for the Afro-American panel

Time frame: Change from baseline (day 0) at days 28 and 56 of application

Dark circles

clinical grading under dermatological control using 1) a 6 points Visual scale of Dermscan from absence (0) to important dark circles (6) for the Asian panel and 2) a 5 points Visual scale of Dermscan from absence (0) to important dark circles (4) for the Afro-American panel

Time frame: Change from baseline (day 0) at days 28 and 56 of application

Relaxed features

clinical grading under dermatological control using a 11 points Non structured scale from relaxed features (0) to looking tired (10) for both panels

Time frame: Change from baseline (day 0) at days 28 and 56 of application

Secondary Outcomes

Subjective evaluation of the product agreeableness and its effects on skin texture, moisture, puffiness, brightness, youth, swelling, wrinkling, radiance and tone.

Self-assessment questionnaire on a 5 points scale from "I disagree" (-2) to "I agree" (+2).

Time frame: At day 28 of application

Subjective evaluation of the product agreeableness and its effects on skin texture, moisture, puffiness, brightness, youth, swelling, wrinkling, radiance and tone.

Data from ClinicalTrials.gov

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