The detection of antiphospholipid antibodies (aPL) is of interest because of their importance in the pathogenesis of arterial or venous thrombosis and their responsibility for a wide spectrum of clinical manifestations such as infection. The aim of the study was to assess the performance of antiphospholipid antibodies biomarker to predict in- hospital mortality in intensive care unit (ICU) septic patient's.
the investigators conducted a prospective single-center observational study including consecutive critically ill septic adults admitted to the intensive care unit. Clinical and laboratory data including chemiluminescence immunoassay for antiphospholipid antibodies \[anticardiolipin (aCL), antiphosphatidylserine (aPS)\] were obtained. Blood samples were collected on days 1, 3, 5, 8 and 10 of hospitalization. The primary study endpoint was ICU mortality defined as death before ICU discharge. Secondary end points included correlation between SOFA score and biological parameters.
Study Type
OBSERVATIONAL
Enrollment
50
Blood samples were collected in dry tubes on days 1, 3, 5, 8 and 10 of hospitalization
Military Hospital of Tunisia
Tunis, Tunisia
RECRUITINGICU mortality
Mortality was defined as death before ICU discharge Multivariate logistic regression modeling will beperformed to found factors associated with higher mortality
Time frame: mortality at day 14 of hospitalization
correlation between SOFA score and antiphospholipid antibodies.
assess correlations between serum levels of both aCL and aPS and SOFA score
Time frame: on days 1, 3, 5, 8 and 10 of hospitalization
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